Inflammation potentiates JMML-like blood defects in Shp2 mutant Noonan syndrome
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
Hematopoietic stem and progenitor cells derived from a zebrafish model of Noonan syndrome, carrying a patient-associated Shp2-D61G mutation, display an expansion of monocyte/macrophage progenitors with an inflammatory gene expression signature. Overall design: CHTs (5dpf) were dissected and dissociated, using FACS sorting HSPCs were isolated and single cell RNA seq was performed.
创建时间：
2024-04-02
