Integrated Gut Microbiota and Metabolomic Profiling Reveals Key Associations between Amino Acid Levels and Gut Microbial Composition in Patients with Obesity

Obesity is an increasingly serious global health concern and is closely associated with gut dysbiosis and metabolic imbalance. Despite the considerable research conducted on the gut microbiota and metabolism over recent years, studies focusing on their correlation with obesity remain limited. In this study, we sought to characterize the gut microbiota and serum metabolic profiles of patients with obesity, aiming to identify potential biomarkers and therapeutic targets for this condition, and explore possible links between altered amino acid levels and gut microbial composition in its pathophysiology. The findings may offer novel insights into obesity prevention and treatment through microbiota modulation or amino acid regulation.