Top 30 Genomic co-events significantly associated with response to the BRAF inhibitor AZ628 in the training set (n = 141 cell lines) and validation in the test set (n = 216).

The frequency of the event in sensitive vs resistant lines is represented by a ratio (freq S/freq R). Events where the ratio is 1.5 are associated with sensitivity. “#DIV0!/infinite” denotes a strong association with sensitivity. Under Test Set, numbers in BOLD indicate events that are significantly associated with S or R: P = 1.5, AND S/R concordant with that of training set. Numbers in ITALICS under Test Set indicate the same but P-value [0.06–0.10]. “No power” for single events under Test Set indicates less than 12% occurrence of the single mutation of interest in the sensitive and resistant lines respectively in the test set. “#N/A” indicates the co-event did not occur for the cell lines studied in the test set. 6/30 (20%) double genomic events that were predictive in the training set were also predictive in the test set at P