SOX9 regulation of Hexokinase 1 controls neuroinflammatory astrocyte subtypes in neuropathic pain (PRJCA036055)

Through a comprehensive approach involving metabolomic, single-cell transcriptomic, epigenomic profiling and regional astrocyte-specific perturbation studies, we identified distinct astrocyte clusters under physiological and pathological pain conditions, and elucidated mechanisms by which metabolic regulation of neuroinflammatory astrocyte subsets during pain pathogenesis.