Functional co-operativity of long-noncoding RNAs at the neuroblastoma susceptibility locus 6p22.3 controls disease progression via USP36-CHD7-SOX9 gene regulatory axis.. Homo sapiens

We report 6p22 locus lncRNAs, which were identified as differentially expressed between high and non-high risk neuroblastoma tumors using RNA sequencing. we identified CASC15-003 and CASC15-004 lncRNAs act as prognostic biomarker in neuroblastoma. Overall design: Functional characterization for CASC15-003 and CASC15-004 lncRNAs was done using knockdown strategies followed by RNA-seq