IL23R gene variants modulate intestinal DMBT1 expression.

The median DMBT1 mRNA expression was analyzed in a total of 75 biopsies from 27 CD patients for each IL23R variant. P values in column (4) are given for the comparison of the DMBT1 expression of carriers of the IL23R minor allele (homozygous and heterozygous) compared to DMBT1 levels in IL23R wild-type carriers. Column (5) summarizes the data from column (3) and represents the fold increase or decrease in DMBT1 expression in carriers of the IL23R minor allele (homozygous and heterozygous) compared to DMBT1 levels in IL23R wild-type carriers for the respective IL23R SNP. The IL-22 serum levels of column 6 summarizes the results of a previous study [34] while the odds ratios of column 7 represent the results of a previous detailed genotype analysis [8], in which all patients analyzed here participated. The correlation coefficient between the DMBT1 quotient of column (5) and the ORs of column (7) is r = 0.766.