Genes with consistent differential expression in the DCN group relative to the Sham group.

*Gene exhibits high relative expression in the pineal gland (see S2 Table).
†Gene has previously been found to be differentially expressed between day and night conditions in microarray experiments (adjusted-p < 0.05).
‡Gene has strong (FC > 4 or FC < 0.25) and statistically significant (adjusted-p < 0.001) differential expression in the Control and/or Sham night/day in vivo analyses (Table 1).
§Gene has strong and statistically significant differential expression in either or both of the treated vs untreated in vitro analyses (Table 3).
These genes displayed significant (adjusted-p < 0.001) differentials across 2 analyses: DCN-day vs Sham-day and DCN-night vs Sham-night. Genes are classified by the least-extreme fold change across both analyses. The complete results for these analyses are available in the SI (S2 Dataset).