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Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

NIAID Data Ecosystem2026-03-11 收录

Hedgehog信号通路

CRISPRi筛选

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP253356 数据链接链接失效反馈

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资源简介：

CRISPR screens to uncover lipid-related genes targeting the hedgehog signaling pathway in NIH-3T3 cells

应用场景：

创建时间：

2020-03-20

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

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Additional file 2: of CRISPRO: identification of functional protein coding sequences based on genome editing dense mutagenesis

CRISPRi筛选

功能蛋白编码序列鉴定

Table S1, Hit analysis RKO, DLD1 and NCI-H1299 cell lines (XLSX 74 kb)

Figshare2018-10-20 更新20

Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

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Genome-scale CRISPRi Perturb-seq on both unstimulated and stimulated Jurkat cells reveals regulators of human T-cell signaling

T细胞信号传导调控

CRISPRi筛选

The goal of the experiment is to identify genes involved in T-cell receptor (TCR) signaling and T-cell activation in human T cells. The Jurkat E6 cell line, engineered to express dCas9-KRAB and transd

NIAID Data Ecosystem20

Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

NIAID Data Ecosystem20

Cholesterol accessibility at the ciliary membrane controls hedgehog signaling

资源简介：

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