Cul4b regulates expansion of the activated CD4+ T cells
收藏NIAID Data Ecosystem2026-03-12 收录
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http://flowrepository.org/id/FR-FCM-Z38M
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资源简介：
Investigate whether Cul4b regulates the proliferation of T cells
Conclusion:
Loss of Cul4b resulted in a decreased frequency of activated (CD44hi) T cells under competitive environment in vivo. Additionally, Cul4b was required for the expansion and pathogenicity of T cells. Co-culture experiments revealed that loss of Cul4b resulted in reduced proliferation and survival of TCR activated CD4+ T cells. Cul4b-deficient T cells acquired more DNA damage and had higher expression of DNA damage recognition proteins.
Notes:
Flow files from different experiments are included To draw any conclusion from the experiments proper controls and replicates were used.
创建时间：
2021-01-01
