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Replication Data for: Mosquitocidal effect and pharmacokinetics of different ivermectin dose regimens in preparation for the BOHEMIA trial: An open label, randomized, controlled clinical trial

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NIAID Data Ecosystem2026-03-14 收录
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https://doi.org/10.7910/DVN/MO6MVV
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资源简介:
This is a replication dataset for the manuscript titled: "Mosquitocidal effect and pharmacokinetics of different ivermectin dose regimens in preparation for the BOHEMIA trial: An open-label, randomized, controlled clinical trial." The related study aimed to provide evidence to support the decision of the dose for the BOHEMIA trials by comparing the pharmacokinetics and mosquito-killing effect of 300 mcg/kg of ivermectin given on three consecutive days to that of 400 mcg/kg of ivermectin given once and validating its sampling method (dried blood spots (DBS)) as a way of assessing concentrations in the field in an East African population. Lastly, we evaluated the mosquitocidal effect of trial comparator albendazole, another anti-infective chosen for its deworming properties which are similar to those of ivermectin. The study is registered with Pan African Clinical Trial Registry identification (PACTR) No.: PACTR202001893991170
创建时间:
2023-03-27
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