Enterocyte-specific deletion of metal transporter Zip14 (Slc39a14) alters intestinal homeostasis through epigenetic mechanisms

Zinc is an essential micronutrient that is believed to influence gut homeostasis by unclear mechanisms. Jimenez et al. identify that zinc transporter Zip14 is essential to maintain protective systems, lower inflammation, and limit dysbiosis through mechanisms that control histone deacetylase activity and transcription factor occupancy of specific genes in intestinal epithelial cells. Overall design: We then performed gene expression profiling analysis using data obtained from RNA-seq of 5 WT and 5 Zip14 KO mice.