Transcriptome analysis of long-lived Drosophila melanogaster E(z) mutants

Histone methylation is critical for Drosophila melanogaster aging, it regulates the chromatin status determining its compactisation and subsequent repression of the genes located in the target heterochromatin domain. In the present work we aim to unravel specific mechanisms which cause life extension, fecundity augmentation and improve stress-response in long-lived E(z) mutants using full transcriptome analysis and approaches for stress-resistance estimation.