Long-term effects of previous EtOH binge drinking after later cocaine withdrawal in adulthood on elevated plus maze: PND 114.

Across PND 68–81 mice (n = 10 per group) were pretreated with Sal or EtOH (1.25 g/kg administered for 16 times in 2 daily i.p. injections separated by a 4-h interval on 2 consecutive days followed by a 48 h “drug-free” period). Twenty one days later, animals were treated with Sal or coca in three daily i.p. injections separated by a 60-min interval according to the ensuing regime: 5 mg/kg on PND 102 and 103, 15 mg/kg from PND 104 to 106, a 2-day abstinence period, and 25 mg/kg from PND 109 to 113.