Transcriptome analysis of cattle experimentally infected with foot-and-mouth disease virus

We present the RNA-seq based transcriptome profile of ventral soft palate tissue from two Indian indigenous breeds (Malnad Gidda and Hallikar; Bos indicus) of cattle and Holstein Friesian (HF) crossbred calves. Differentially expressed gene pattern showed stronger innate immune response in the indigenous calves. We find that induction of innate and cell mediated immune response is associated with early viral clearance and mild form of foot-and-mouth disease. RNA-sequencing was performed at Sandor Life Sciences Pvt. Ltd., Hyderabad (India) on Illumina HiSeq (151 nt, paired-end) platform, using RNA isolated from ventral soft palate tissue of three breeds of cattle. Number of of samples of each breed included three (n=3) infected with FMDV and two mock controls (n=2). In total there were nine cattle calves infected with FMDV and six mock control calves.