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Integrative Analysis Identifies Key Molecular Signatures Underlying Neurodevelopmental Deficits in Fragile X Syndrome

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NIAID Data Ecosystem2026-04-25 收录
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We report the generation of isogenic hPSC model of FXS and characterize the neurodevelopmental capacity of these cells, performed transcriptome profiling in FXS neurons and identified key pathways Overall design: Transcriptome profiling of FXS-derived neurons from hESC generated by RNA-seq in four replicates per genotype for using Illumina HiSeq4000. Control and FXS-derived neurons from hiPSC were generated by RNA-seq in 3 replicates per genotype.

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2020-09-09
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