官方服务：
资源简介：
To develop a genome tool with high efficiency in in vivo study
应用场景：
创建时间：
2023-02-03
相关数据集
In vivo base editing extends lifespan of a humanized mouse model of prion disease
Prion disease is a fatal neurodegenerative disease caused by the misfolding of prion protein (PrP) encoded by the PRNP gene. While there is currently no cure for the disease, depleting PrP in the brai
NIAID Data Ecosystem80
PpCas9 from Pasteurella pneumotropica - a compact Type II-C Cas9 ortholog active in human cells. Part 2
Characterization Type II-C CRISPR Cas systems from Defluviimonas sp. 20V17 and Pasteurella pneumotropica. Illumina sequencing reads from PpCas9 specificity tests.
NIAID Data Ecosystem60
In vivo base editing by a single intravenous vector injection for the treatment of hemoglobinopathies
Individuals with beta-thalassemia or Sickle Cell Disease and hereditary persistence of fetal hemoglobin (HPFH) possessing 30% HbF appear to be symptom-free. Here, we used a non-integrating HDAd5/35++
NIAID Data Ecosystem30
Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications
Exploiting Activation and Inactivation Mechanisms in Type I-C CRISPR-Cas3 for Genome Editing Applications Descriptor: AcrIC9, Cas11, Cas5, ... Authors: Hu, C, Nam, K.H, Ke, A. Deposit date: 2023-02-22
Protein Data Bank Japan2025-05-21 更新80
Cascade complex from type I-A CRISPR-Cas system
Cascade complex from type I-A CRISPR-Cas system Descriptor: Cas11a, Cas5a, Cas7a, ... Authors: Hu, C, Ni, D, Nam, K.H, Majumdar, S, McLean, J, Stahlberg, H, Terns, M, Ke, A. Deposit date: 2022-01-28 R
Protein Data Bank Japan2024-11-13 更新40
