AK6 phosphorylates (d)NMPs to (d)NDPs

Adenylate kinases (AKs) are nucleoside monophosphate kinases, which catalyze the phosphorylation of AMP by using ATP or GTP as phosphate donors. AKs are thus involved in maintaining the homeostasis of cellular nucleotides. CMP, dCMP and dAMP are other substrates phosphorylated with less efficiency by AKs. When GTP is the phosphate donor, only AMP and CMP are efficiently phosphorylated. Adenylate kinase 6 (AK6) is thought to mediate nucleotide homeostasis in the nucleoplasm (Ren et al. 2005).

腺苷酸激酶（AKs）为核苷单磷酸激酶，催化AMP的磷酸化反应，以ATP或GTP作为磷酸供体。因此，AKs在维持细胞核苷酸稳态中发挥着重要作用。CMP、dCMP和dAMP是AKs以较低效率磷酸化的其他底物。当GTP作为磷酸供体时，仅AMP和CMP能被高效磷酸化。腺苷酸激酶6（AK6）被认为在细胞核质中调节核苷酸稳态（Ren等，2005年）。