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BMI1 regulates human erythroid self-renewal through both repressive and activating chromatin associations [Cut&Run]

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NIAID Data Ecosystem2026-05-02 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE253289
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To gain insights into the mechanisms underlying BMI1 activity we assessed binding of BMI1, the PRC1 member RING1B, and the PRC-associated histone marks H3K27me3 and H2AK119ub in SREs and in iSREs. Cut&Run was used to profile PRC1 complex members Bmi1, Ring1b, H2AK119Ub, and H3K27me3 in SRE cells (untransduced) and iSRE cells (overexpressing Bmi1)
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2025-08-27
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