Intraindividual epigenetic heterogeneity underlying phenotypic subtypes of advanced prostate cancer [ChIP-seq]

Prostate cancer is characterized as being histologically and molecularly heterogeneous. Additionally, epigenetic changes play an important role in regulating the progression of prostate cancer. However, epigenetic intraindividual heterogeneity is largely unknown in advanced prostate cancer. Hence, the epigenetic profiles of advanced prostate cancer, including autopsy cases, were investigated. Overall design: ChIP-seq analysis for histone modifications on samples from advanced prostate cancer patients