Effect of subcutaneous fat (SF) loss on gene expression with clear cell renal cell carcinoma

RCC is one of known malignancies in terms of the association between body mass index (BMI), adiposity, and prognosis, showing overall survival (OS) improvement in obese patients. Despite of increasing interest in this unexpected survival benefit of obesity, termed the “obesity paradox”, previous studies focused on the baseline features without considering their changes. Given that these changes, especially for rapid loss of adipose tissue, are also reported to have a prognostic value in cancer patients, and that ICI therapy can lead to substantial change in body composition, it may be reasonable to assume that these changes are also associated with patient prognoses. However, its prognostic impact on patients with metastatic ccRCC undergoing ICI therapy has not been established. In this study, We investigated the association between these changes and molecular features by targeted sequencing and RNA sequencing of tumor samples to understand the underlying biology. Comparative gene expression profiling analysis of RNA-seq data between ccRCC with delta SF0 and ccRCC with delta SF1