Tensile strain and altered synovial tissue metabolism in human knee osteoarthritis

To investigate the physiologic responses of whole osteoarthritic synovium to cycle tensile strain. We obtained 3 matched synovial tissue samples from 6 patients undergoing total knee arthroplasty, subjected them to cyclic tensile strain, and then performed gene expression profiling analysis using RNA seq from each cyclic tensile strain protocol. Comparative gene expression profiling analysis of RNA-seq data for whole osteoarthritis synovium subjected to 3 different cyclic tensile strain protocols (control (static), low-frequency (0.3Hz), and high-frequency (1.0Hz)).