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The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

NIAID Data Ecosystem2026-03-08 收录

Th17/Treg分化调控

DYRK1A

数据链接：

https://www.ncbi.nlm.nih.gov/bioproject/PRJNA281376 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

应用场景：

创建时间：

2015-04-16

自闭症谱系障碍遗传

DYRK1A

Variant information for known de novo DYRK1A mutation cases. Full variant information for previously published DYRK1A variants and patients seen at UW. Previously published cases identified by first a

Figshare2017-10-06 更新60

The DYRK1A kinase positively regulates angiogenic responses in endothelial cells

血管生成调控

DYRK1A

Angiogenesis is a highly regulated process essential for organ development and maintenance, and its deregulation contributes to inflammation, cardiac disorders and cancer. The Ca2+/Nuclear Factor of A

NIAID Data Ecosystem40

The DYRK1A protein kinase is recruited to a subset of ribosomal protein gene promoters in human and mouse cells [RNA-seq]

核糖体蛋白基因

DYRK1A

Ribosomal protein genes (RPGs) coding sequences are highly conserved along evolution; however, promoter features and the machinery involved in their transcriptional regulation are not. In eukaryotes,

NIAID Data Ecosystem20

Cyclic AMP-responsive element-binding protein (CREB) is critical in autoimmunity by promoting Th17 but inhibiting Treg differentiation

自身免疫疾病

Th17/Treg分化调控

The molecular mechanisms that govern differential T cell development into pro-inflammatory Th17 vs. regulatory T (Treg) cells remain unclear. Here, we show that selective deletion of CREB in T cells o

NIAID Data Ecosystem60

Control of the mitochondrial carrier import pathway by DYRK1A

线粒体蛋白质

DYRK1A

Mitochondria require a complete and functional proteome to maintain a plethora of metabolic reactions in a cell. Changes in cellular demands depend on a rapid adaptation of the mitochondrial proteome.

NIAID Data Ecosystem40

The kinase DYRK1A reciprocally regulates the differentiation of Th17 and regulatory T cells

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