Bioenergetics status determines motor neuron vulnerability in spinal muscular atrophy. Mus musculus

Comparative gene expression profiling of motor neurons innervating the extensor digitorum longus (disease-resistant), gastrocnemius (intermediate vulnerability), and tibialis anterior (vulnerable) muscles in mice to determine the factors underlying their selective vulnerability in sinal muscular atrophy. Overall design: Gene expression profiling utilised total RNA extracted from motor neurons derived from normal mice on an SMA background to investigate selective vulnerability of motor neurons