Profiling gene expression changes in the epidermis of embryonic murine Harlequin Icthyosis skin

Gene expression analysis of the epidermis from Lexicon Genetics Abca12 knockout mouse model of Harlequin Ichythois compared with wild type embryos to search for pathways specifically altered in the condition. Results indicate a large immune and inflammatory response occurs in the sterile environment of the uterus. Total RNA isolated from E17.5 back skin epidermis from murine Harlequin Ichthyosis model compared with wild type embryos.本数据集针对豪猪鱼鳞病（Harlequin Ichthyosis）的Lexicon Genetics Abca12基因敲除小鼠模型的表皮开展基因表达分析，并以野生型胚胎作为对照，旨在筛选该疾病中特异性发生改变的信号通路。研究结果表明，在子宫的无菌环境中会出现显著的免疫与炎症反应。实验所用总RNA（Total RNA）提取自胚胎发育第17.5天（E17.5）的小鼠背部皮肤表皮，样本分别来自豪猪鱼鳞病模型小鼠与野生型胚胎。