B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity

ChEBI2014-12-04 更新2026-07-21 收录

B细胞淋巴瘤机制

表观遗传调控与肿瘤发生

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-62063 数据链接链接失效反馈

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B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity

创建时间：

2014-12-04

TET deficiency promotes oncogenesis and DNA damage in B cells by increasing the levels of G-quadruplexes and R-loops [RNA-seq]

B细胞淋巴瘤机制

TET缺失与DNA损伤

Enzymes of the TET family are methylcytosine dioxygenases that undergo frequent mutational or functional inactivation in both hematological and solid cancers. Recent studies have identified recurrent

NIAID Data Ecosystem60

Distinct roles of PARP-1 and PARP-2 in c-Myc-driven B cell Lymphoma in mice

B细胞淋巴瘤机制

PARP蛋白功能分析

To study the implication of PARP-1 deficiency or PARP-2 deficiency in the development of c-Myc overexpression-induced B lymphomas, we have studied by RNAseq the gene expression profile in pre-B cells

NIAID Data Ecosystem30

Concurrent activation of NF-kB and Notch signaling is sufficient to induce B cell transformation and enables B-myeloid conversion

B细胞淋巴瘤机制

信号通路调控

Comparison of transcriptome between control, NF-kB, Notch and NF-kB singly- and doubly-activated spleen marginal zone or precursor B cells, and transformed doubly-activated lymphoma cells Control, NF

NIAID Data Ecosystem20

Gene expression profile analysis of germinal center B cells from conditional Crebbp knockout mice and littermate controls. Mus musculus

B细胞淋巴瘤机制

基因表达谱分析

Inactivating mutations of the gene encoding for the CREBBP acetyltransferase are highly frequent in diffuse large B cell lymphoma (DLBCL, 30% of cases) and follicular lymphoma (FL, 60% of cases), the

NIAID Data Ecosystem40

Enhancer Sequence Variants and Transcription Factor Deregulation Synergize to Construct Pathogenic Regulatory Circuits in B Cell Lymphoma

B细胞淋巴瘤机制

增强子-转录因子调控

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

NIAID Data Ecosystem30