Accelerated Discovery of Potent Fusion Inhibitors for Respiratory Syncytial Virus
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https://figshare.com/articles/dataset/Accelerated_Discovery_of_Potent_Fusion_Inhibitors_for_Respiratory_Syncytial_Virus/12155841
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资源简介：
A series of five benzimidazole-based
compounds were identified using a machine learning algorithm as potential
inhibitors of the respiratory syncytial virus (RSV) fusion protein.
These compounds were synthesized, and compound 2 in particular
exhibited excellent in vitro potency with an EC50 value of 5 nM. This new scaffold was then further refined
leading to the identification of compound 44, which exhibited
a 10-fold improvement in activity with an EC50 value of
0.5 nM.
创建时间：
2020-04-10
