Dataset from An Exploratory, Randomised, Double-blind, Double-dummy, Active-controlled, Two Period Cross-over Study to Investigate the Effect of 6 Weeks Treatment of Orally Inhaled Tiotropium + Olodaterol Fixed Dose Combination (FDC) Delivered by the Respimat® Inhaler With Fluticasone Propionate + Salmeterol FDC Delivered by the Accuhaler® Inhaler, on Left Ventricular Function and Arterial Stiffness in Patients With Chronic Obstructive Pulmonary Disease (COPD)

The objectives of the study are to explore the effect of treatment with tiotropium +
olodaterol fixed dose combination (FDC) compared to fluticasone propionate + salmeterol FDC
on:

- reversal of left ventricular diastolic dysfunction assessed with cardiac magnetic
resonance (CMR) imaging,

- measures of arterial stiffness assessed by CMR and pulse wave analysis (PWA),

- reduction of hyperinflation assessed with body plethysmography and

- post dose spirometry.