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scRNA seq analysis of adult CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia

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NIAID Data Ecosystem2026-03-12 收录
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We demonstrate that ex vivo culture of human adult hematopoietic stem and progenitor cells with Delta1ext-IgG under hypoxia limits endoplasmic reticulum stress in long-term repopulating hematopoietic stem cells and, to a lesser extent, in lineage committed progenitors compared to normoxic cultures. Data were submitted on behalf of Dr. Larochelle's lab at the NIH. RNA-seq of G-CSF mobilized CD34+ cells ex vivo cultured with Delta1ext-IgG under normoxia or hypoxia

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2021-10-06
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