Murine leukemia virus P50 protein counteracts APOBEC3 by blocking its packaging
收藏NIAID Data Ecosystem2026-03-11 收录
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MLV has existed in mice for at least a million years, in spite of the existence of host restriction factors that block infection. Although MLV is considered a
simple retrovirus compared to lentiviruses, it does encode proteins generated from
alternatively spliced RNAs. Here, we show that P50, generated from an alternatively
spliced RNA encoded in gag, counteracts APOBEC3 by blocking its packaging. MLV
also encodes a protein, glycoGag, that increases capsid stability and limits APOBEC3
access to the reverse transcription complex (RTC). Thus, MLV has evolved multiple
means of preventing APOBEC3 from blocking infection, explaining its survival as an
infectious pathogen in mice.
创建时间：
2020-07-11
