Supplementary data: Comparison treatments for basal ganglia hemorrhage: minimally invasive puncture and drainage versus craniotomy versus conservative treatment

These are peer-reviewed supplementary materials for the article 'Comparison treatments for basal ganglia hemorrhage: minimally invasive puncture and drainage versus craniotomy versus conservative treatment' published in the Journal of Comparative Effectiveness Research.eTable 1: Association of MIPD and conservative treatment with clinical outcomeseTable 2: Association of craniotomy and MIPD with clinical outcomeseTable 3: Association of craniotomy and conservative treatment with clinical outcomeseTable4: Baseline characteristic for patients with in basal ganglia hematoma of 30 ml or moreAim: The optimal management strategies for spontaneous intracerebral hemorrhage in the basal ganglia region are still controversial. The purpose of the present study is to evaluate the clinical benefits of craniotomy,minimally invasive puncture and drainage (MIPD) and conservative treatment in patients with basal ganglia hematoma. Materials & methods: This study retrospectively enrolled consecutive patients with hematoma ≥20 ml in the basal ganglia hemorrhage and onset to admission within 24 h. Primary outcome was the proportion of favorable outcome (modified Rankin scale score 0–3) at 3 months. Secondary outcomes included excellent outcome (modified Rankin scale score 0–2) and mortality at 3 months and 1 year. Sensitive analysis was performed in patients with hematoma ≥ 30 ml. Results: A total of 481 patients were included and divided into three groups: 146 received craniotomy, 211 underwent MIPD and 124 were managed with conservative treatment. The proportion of primary outcome was lower in the craniotomy (23.24%) than in the MIPD (35.41%) and conservative treatment (41.94%) groups. Among patients with hematoma ≥30 ml,MIPD has higher rates of favorable outcome at 3 months (37.32 vs 25.98%, p = 0.05) and 1 year (52.82 vs 40.16%, p = 0.04) compared with craniotomy; albeit. The short-term and long-term mortality was similar in three groups. Conclusion: MIPD was found to be associated with both short- and long-term favorable outcomes in patients with spontaneous intracerebral hemorrhage in the basal ganglia region. Moreover, neither MIPD nor craniotomy showed an association with increased risk of short- or long-term mortality.