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Transcription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series

ChEBI2008-06-15 更新2026-07-21 收录

糖皮质激素受体功能研究

肉瘤转录组学

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-6711 数据链接链接失效反馈

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Transcription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series

应用场景：

创建时间：

2008-06-15

肉瘤转录组学

药物靶点鉴定

To gain insight into the Anticarin-Ã target gene profile in osteosarcoma cells, we performed RNA-seq analysis in MG63 cells upon CCT4 siRNA-mediated knockdown (siCCT4) or Anticarin-Ã. Overall desi

NIAID Data Ecosystem70

GRα-independent transcriptional activity of hGRβ in GR Liver Knockout Mouse

糖皮质激素受体功能研究

肝脏基因转录调控

We used AAV as a vector to deliver hGRβ to the liver of GR Liver Knockout mice. We collected liver samples for microarray analysis to investigate any phenotype as well as the underlying specific signa

NIAID Data Ecosystem60

Transcriptome analysis of osteosarcoma cell lines treated with FDA-approved drugs

肉瘤转录组学

抗肿瘤药物作用机制

In order to understand the effect of FDA-approved drugs including doxorubicin (DOX) and HDACs inhibitors (PXD101 and PCI-24781) on osteosarcoma, 143B osteosarcoma cells were treated with the single ag

NIAID Data Ecosystem40

Full-length transcriptome sequencing reveals gene expression signatures in human soft tissue sarcomas. Full-length transcriptome sequencing reveals gene expression signatures in human soft tissue sarcomas

肉瘤转录组学

凋亡基因表达

Soft tissue sarcomas (STSs) are heterogeneous malignancies derived from mesenchymal cells. Due to its rarity, heterogeneity, and limited overall response to chemotherapy, STSs represents a therapeutic

NIAID Data Ecosystem70

hGRβ: Elucidation of its Role in Transcriptional Regulation and Identification of a Ligand. Homo sapiens

糖皮质激素受体功能研究

转录调控机制

The human glucocorticoid receptor (GR) is expressed as two alternately spliced Cterminal isoforms: α and β. In contrast to the canonical hGRα, hGRβ is constitutively nuclear, is not thought to bind li

NIAID Data Ecosystem60

Transcription profiling of human U-2 osteosarcoma cell lines expressing different glucocorticoid receptor isoforms - time series

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