Supporting data for the study "Bruceantinol targeting GPX4 triggers ferroptosis in cervical cancer"

1、Research Data: Raw Data (Excel file) Complete numerical dataset underlying all graphs and statistical analyses presented in the main figures (CCK‑8, LDH, ROS, JC‑1, Fe²⁺, SOD, GSH, etc.). 2、Research Data: Analysis of DEGs in Cervical Cells (Excel file) Full list of differentially expressed genes (DEGs) identified by transcriptome sequencing in BOL‑treated versus control HeLa and SiHa cells, including Log₂ fold change and adjusted p‑values. 3、Research Data: Original Western Blots (PDF file) Uncropped, full‑length scans of all Western blot membranes with clearly visible molecular weight markers, corresponding to all WB panels in the main text. 4、Research Data: Molecular Docking (ZIP archive) This archive contains the input and output files for molecular docking of BOL with GPX4. Included files: (1) GPX4-AF-A0A0A0MTT1-F1-model_v6_model1.pdbqt: GPX4 protein structure in PDBQT format (prepared with assigned charges and polar hydrogens). (2) BOL-MOL008076_out.pdbqt: BOL ligand structure in PDBQT format (optimized with rotatable bonds defined). (3)BOL-GPX4 complex.pdb: docked complex structure in PDB format, representing the predicted binding pose of BOL with GPX4. All files are named according to their function and are ready for visualization or re‑analysis using standard molecular docking software (e.g., AutoDock Vina, PyMOL, or Discovery Studio). 5、Research Data: Molecular Dynamics Simulation (ZIP archive) Complete trajectory and parameter files for the 200‑ns MD simulation of the GPX4–BOL complex, including RMSD, RMSF, Rg, SASA, and hydrogen bond occupancy data.