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Loss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability

ChEBI2014-11-06 更新2026-07-21 收录

RNA表观遗传学

智力障碍疾病模型

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-44746 数据链接链接失效反馈

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资源简介：

Loss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability

应用场景：

创建时间：

2014-11-06

RNA表观遗传学

m6A修饰机制

N6-methyladenosine (m6A) is the most common prevalent internal modifications found in many of the eukaryotic mRNA and plays an important role in RNA metabolism including pre-mRNA processing, mRNA stab

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m6A IP sequencing analysis of m6A mRNA methylation regulation by FTO in melanoma cells. m6A IP sequencing analysis of m6A mRNA methylation regulation by FTO in melanoma cells

RNA表观遗传学

黑色素瘤分子机制

N6-methyladenosine (m6A) RNA methylation is the most abundant internal chemical modifications in eukaryotic messenger RNA (mRNA) as well as long non-coding RNA (lncRNA). Recently, m6A RNA methylation

NIAID Data Ecosystem50

RNA m6A modification mediated by METTL3 is important for IAP heterochromatin integrity in mESCs (MeRIP-Seq)

RNA表观遗传学

细胞染色质调控

N6-methyladenosine (m6A) methyltransferase METTL3 mainly mediates mRNA m6A methylation and plays important roles in various biological processes. Here we report a chromatin-based role for METTL3 in he

NIAID Data Ecosystem50

Targeting tumor-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy. Targeting tumor-intrinsic N7-methylguanosine tRNA modification inhibits MDSC recruitment and improves anti-PD-1 efficacy

肿瘤免疫治疗

RNA表观遗传学

We found that PMN-MDSCs level is elevated in the advanced ICCs tissues and is positively associated with the METTL1 and m7G tRNA modification levels. We further showed that impaired m7G tRNA modificat

NIAID Data Ecosystem50

m6A MeRIP-seq of different rice varieties

RNA表观遗传学

遗传变异

m6A MeRIP-seq was performed to investigate the divergent m6A modification patterns among different varieties of Oryza sativa at the transcriptome level.

NIAID Data Ecosystem50

Loss of cytosine-5 methylation in tRNA triggers stress responses in a disease model for Intellectual Disability

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