Supplemental material for "Time-course characterization of a systemic wasting-associated HFpEF-like phenotype in HFD+L-NAME-loaded Wistar rats"

This record contains Supplemental Figures S1–S2 and Supplemental Tables S1–S4 supporting the manuscript entitled “Time-course characterization of a systemic wasting-associated HFpEF-like phenotype in HFD+L-NAME-loaded Wistar rats,” submitted to the American Journal of Physiology-Heart and Circulatory Physiology. Supplemental Figures S1–S2 present selected plasma biochemical variables, total nitrite and nitrate concentrations, within-time-point myocardial RNA-sequencing patterns, and exploratory direction-specific association networks. Supplemental Tables S1–S4 provide cohort accounting and analysis rules, individual phenotype data, differential gene-expression and cross-cohort reproducibility results, and detailed pathway and network-analysis results.