Apple derived exosomes exert anti-inflammageing effect onto the skin trough NF-kB pathway

Skin ageing is strictly related to chronic inflammation of the derma and decay of structural pro-teins of the extracellular matrix. In fact, it has become common practice to refer to this phenomenon as inflammageing. Biotech innovation for products that induce a youthful appearance, are always in search of new active principles. In this paper, apple-derived nanovesicles (ADNVs) have been investigated as novel anti-inflammatory compounds, which are able to alter the extra-cellular matrix production of dermal fibroblasts. Total RNA sequencing analysis revealed that ADNVs negatively influence the activity of Toll-like Receptor 4 (TLR4), and thus downregulate the NF-kB pro-inflammatory pathway. Topic applications for skin regeneration were evaluated by association of ADNVs with hyaluronic acid (HY) -based hydrogel and patches