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Investigation of regulatory mechanism of NDRG1 by non-coding RNA upon reoxygenation

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https://www.ncbi.nlm.nih.gov/sra/SRP062087
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In our previous genomic study of breast cancer cells upon reoxygenation, we identified that NDRG1 had the maximal response. NDRG1 is reported to be expressed ubiquitously in tissues stimulated under a wide variety of stress and cell growth-limited conditions. Therefore, we hypothesize that NDRG1 may play an important role in tumor adaptation to fluctuation of oxygen concentrations. Although several studies suggested that NDRG1 is induced by hypoxia and associated with metastasis, the regulatory mechanism of NDRG1 remains elusive and its function under reoxygenation is still unclear.
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2017-09-17
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