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DNA methylation in AgRP neurons regulates voluntary exercise behaviour in mice

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Knock out of Dnmt3a in AgRP neurons leads to a sedentary, adiposity-prone adult phenotype associated with widespread changes in DNA methylation and gene expression. Genome-wide bisulfite-seq and RNA-Seq of FACS-sorted neural (NeuN+) nuclei from the arcuate nucleus of the hypothalamus.

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2019-12-10
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