Dataset HPV ITS y2021m04 [51]

Detection of Human papillomavirus and co-infection with other sexually transmitted pathogens in northern PeruABSTRACT BackgroundHuman papillomavirus (HPV) infection is the most common sexually transmitted infection worldwide. High-risk HPV strains are a necessary but not a sufficient cause for cervical cancer and the presence of other co-factors may facilitate progression to cancer. The presence of other sexually transmitted infections (STIs) may be associated with greater progression of cervical lesions. ObjectiveThe aim of this study was to identify HPV infections and the presence of co-infections by other important STIs (Chlamydia trachomatis, Trichomonas vaginalis, and Herpes simplex virus 2) in women attending the public health system in northern Peru. MethodsWe conducted a prospective cross-sectional study in asymptomatic women attending the cervical cancer screening program in a public hospital of Cajamarca, Peru. Detection of sexually transmitted pathogens was performed by polymerase chain reaction (PCR). The pathogens evaluated were: HPV, Chlamydia trachomatis, Trichomonas vaginalis, and Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) . ResultsA total of 300 asymptomatic women were enrolled in the current study. The pooled prevalence of HPV detected in our study was 19.33% (16.33% as single infection and 3.00% in co-infections) from the total samples.Co-infections between the different pathogens were also observed in 15 cases, being HPV and T. vaginalis the most frequent with 10 cases (66.67%). The most frequent type identified in HPV monoinfections were HPV-16 (16.33%), HPV-52 (14.29%) and HPV-31 (8.16%). Co-infection by multiple HPV types were also identified with up to 4 genotypes at the same time in a single patient The majority of patients with high-risk HPV were between 18 - 39 years old (60.87%) and had a sexual partner in the last 6 months (93.48%). Also, the majority of the patients with high-risk types did not report frequent condom use (89.13%). Keywords: HPV, Human papillomavirus, Herpes, Herpes virus simple, Chlamydia trachomatis, Trichomonas vaginalis