Mcl1

ENCODES a protein that exhibits BH domain binding; protein dimerization activity; protein-containing complex binding; INVOLVED IN negative regulation of apoptotic process; DNA damage response (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Barrett's esophagus (ortholog); colon cancer (ortholog); colorectal cancer (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene

编码一种具有BH结构域结合、蛋白质二聚化活性、蛋白质复合物结合活性的蛋白质；参与负向调控细胞凋亡过程、DNA损伤反应（同源）；在无配体存在的情况下，参与外源性细胞凋亡信号通路（同源）；参与内源性细胞凋亡途径、低氧诱导因子通路、白细胞介素-6信号通路；与Barrett食管（同源）、结肠癌（同源）、结直肠癌（同源）相关；存在于Bcl-2家族蛋白复合物（同源）、细胞质（同源）、细胞溶质（同源）；与1,1,1-三氯-2-(邻氯苯基)-2-(对氯苯基)乙烷、2,3,7,8-四氯二苯并-对氧杂芴、2,4-二硝基甲苯相互作用。