Spotting a Conglomerate Is Just Halfway to Achieving a Preparative Resolution by Preferential Crystallization

Nowadays the detection of conglomerates has been improved; but with a view to implement an efficient preparative resolution by preferential crystallization, this is not enough. Indeed, when a conglomerate has been spotted, there is no other way to assess the feasibility of its preferential crystallization than to run various tests of entrainment. Three similar molecular structures in the series of 1,2-diaminocyclohexyl derivatives are presented in this work. The structures correspond to conglomerates with nonobvious stoichiometry. Two are successfully resolved by preferential crystallization; the third one cannot be resolved by entrainment.