ROC-Datas–Measuring the sensitivity of SiteMotif against existing site alignment tools.

Two independent exercises were carried out to test the alignment capabilities. A) Easy target—Comprises a list of proteins originating from the same SCOP folds and recognizes the same ligand but belongs to a different family. The compared proteins share a pretty good similarity in the binding site and hence have to be picked correctly. B) Hard target—Constitute pairs of protein that binding with the same ligand but are placed in different SCOP folds. As such that they don’t share any structural similarity between them.
(XLSX)