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Regulation of HLA II expression in acute myeloid leukemia by CIITA methylation (RNA-seq dataset)

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NIAID Data Ecosystem2026-03-11 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE150372
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Acute myeloid leukemia cell lines were treated with the hypomethylating agent decitabine and interferon gamma to investigate if these treatments induce HLA II gene expression. Cells carrying either control or CIITA-targeting sgRNAs were used to test the dependence of the HLA II induction on CIITA. RNA sequencing data were obtained from acute myeloid leukemia cell lines treated with decitabine and/or interferon gamma and subjected to CRISPR-mediated disruption of CIITA.
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2020-07-20
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