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Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

Mendeley Data2020-06-12 更新2026-04-09 收录

结核病免疫病理学

多重组织成像分析

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Multiplexed imaging data associated with "Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood"

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2020-06-12

结核病免疫病理学

肉芽肿病理机制

Using the zebrafish-M. marinum model, we identify the basis of granuloma macrophage transformation. Single-cell RNA-seq analysis of zebrafish granulomas as well as analysis of M. tuberculosis-infected

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Impaired M. tuberculosis Antigen-Specific IFN-γ Response without IL-17 Enhancement in Patients with Severe Cavitary Pulmonary Tuberculosis

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BackgroundTh1 cells play an essential role in immune protection against tuberculosis. Th17 cells might be involved with immune pathology in active human tuberculosis (TB). The balance between Th1 and

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Helminth-induced arginase-1 exacerbates lung inflammation and disease severity in tuberculosis.

结核病免疫病理学

蠕虫共感染免疫调节

We analyzed gene expression in CD4+ cells sorted from naïve or D30 Mycobacterium tuberculosis-infected mice and incubated in vitro in the presence or absence of Schistosoma egg antigen. We found gene

NIAID Data Ecosystem10

MMPs and NETs are detrimental in CNS-tuberculosis with MMP inhibitor doxycycline improving murine CNS-tuberculosis survival (human)

结核病免疫病理学

空间转录组学

Despite effective anti-tuberculous treatment (ATT), up to 40% of patients with central nervous system tuberculosis (CNS-TB) suffer permanent neurological deficits and death. The immunopathological mec

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Single-Cell Sequencing Unveils the Cellular Characteristics Underlying the Onset and Progression of Hematogenous Disseminated Tuberculosis

结核病免疫病理学

单细胞转录组学

The etiology of hematogenous disseminated tuberculosis (DTB) likely involves multiple factors, though it remains incompletely understood. In this study, we performed single-cell RNA transcriptome and

NIAID Data Ecosystem10

Multiplexed imaging of human tuberculosis granulomas uncovers immunoregulatory features conserved across tissue and blood

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