Human KRas4A (GMPPNP) in complex with compound 36

Human KRas4A (GMPPNP) in complex with compound 36 Descriptor: (3Z)-18-(4-aminocyclohexyl)-21-[4-(4-amino-1-piperidyl)-1-piperidyl]-7-chloro-10-hydroxy-2,2-dioxo-2-lambda-6,5-dithia-3,12,18,22-tetrazatetracyclo[18.3.1.04,12.06,11]tetracosa-1(23),3,6,8,10,20(24),21-heptaen-19-one, COBALT (II) ION, GTPase KRas, ... Authors: Schuettelkopf, A.W. Deposit date: 2024-08-14 Release date: 2025-04-16 Last modified: 2025-05-21 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Reversible Small Molecule Multivariant Ras Inhibitors Display Tunable Affinity for the Active and Inactive Forms of Ras. J.Med.Chem., 68, 2025