LAR1 activates NF-κB signaling pathway by binding to APOC1 mRNA and enhancing its expression: A novel mechanism underlying breast carcinogenesis

The transcriptomic changes induced by LAR1 overexpression was profiled using mRNA sequencing on LAR1-overexpressing MDA-MB-231 cells and vector controls. DEGs were defined as those with a |Log2FC| > 1.5 and a p value < 0.01. To distinguish direct targets of LAR1, we intersected these DEGs with a previously published LAR1-mRNA interactome dataset generated by RNA immunoprecipitation and microarray profiling (RIP-CHIP).
, , # Data from: LAR1 activates NF-κB signaling pathway by binding to APOC1 mRNA and enhancing its expression: A novel mechanism underlying breast carcinogenesis

Dataset DOI: [10.5061/dryad.s4mw6m9kn](https://doi.org/10.5061/dryad.s4mw6m9kn)

## Description of the data and file structure

RNA immunoprecipitation and microarray profiling (RIP-CHIP) follows Mura et al., 2015.

Mura M., Hopkins T.G., Michael T., Abd-Latip N., Weir J., Aboagye E., Mauri F., Jameson C., Sturge J., Gabra H., Bushell M., Willis A.E., Curry E., Blagden S.P., 2015. LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression. Oncogene 34(39):5025-36.

### Files and variables

#### File: Shared_genes-Down.xlsx

**Description:** The shared genes between downregulated DEGs of mRNA-sequencing from MDA-MB-231 cells (Lv-LAR1 vs Lv-Vector) and the previously published LAR1-mRNA interactome ([https://doi.org/10.1038/onc.2014.428](https://doi.org/10.1038/onc.2014.428)).

#### File: Shared_genes-Up.xlsx
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