Identification of target genes of TAZ in the prostate cancer cells. Homo sapiens

We found that the transcriptinal co-activator TAZ is a basal cell marker for the prostate epithelium which is lost in the prostate cancer tissues and re-expression of TAZ in the prostate cancers may be a indicator of malignancy. TAZ promotes cell migraiton, EMT and metastasis in the prostate cancers. To elucidate the underlying mechanism, we performed the RNA-seq analysis of TAZ knockdown DU145 cells using two independent TAZ shRNA and pLKO control cells. Overall design: Two TAZ knockdown DU145 cells using two independent TAZ shRNA and two pLKO control DU145 cells were used for RNA-seq.