Network-based integrative analysis of lithium response in bipolar disorder using transcriptomic and GWAS data

Lithium is the gold standard treatment for bipolar disorder. The goal of this study was to identify gene expression networks associated with lithium response. RNAseq data was obtained from IPSC derived neurons from lithium responders and non-responders. Focal adhesion was the network most associated with response. Overall design: Hippocampal neurons were derived from IPSCs from 6 lithium responders, 6 non-responders, and 6 controls. All groups were treated with and without lithium in vitro and RNAseq data obtained.