Crystal structure of KRAS-G12D (GMPPNP-bound) in complex with BBO-11818
收藏Protein Data Bank Japan2026-04-15 更新2026-04-19 收录
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Crystal structure of KRAS-G12D (GMPPNP-bound) in complex with BBO-11818 Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... Authors: Chan, A.H, Bratcher, D.R, Simanshu, D.K. Deposit date: 2025-06-16 Release date: 2025-12-03 Last modified: 2026-04-15 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Discovery of BBO-11818, a Potent and Selective Noncovalent Inhibitor of (ON) and (OFF) KRAS with Activity against Multiple Oncogenic Mutants. Cancer Discov, 16, 2026
创建时间：
2025-06-16
