Characteristics of patients with GBM at first recurrence.

Necrosis (+) and (-) indicate that the tumor showed, respectively, the presence or absence of expanding area of necrosis (see Fig. 2). M = Male. F = Female. Age = age at initial diagnosis in years. Initial Therapy = therapy given prior to first recurrence. Surgery = initial surgical procedure at the time of diagnosis. Chemo + Bev = chemotherapy given with bevacizumab. XRT = radiation therapy. Tem = Temozolomide. XRT/Tem = radiation therapy with concurrent Temozolomide. XRT, Tem = radiation therapy followed by Temozolomide. CCNU = Lomustine. CPT-11 = Irinotecan. STR = subtotal resection. ICT-107 = ICT-107 vaccine. Gliadel = Gliadel wafers. GTR = gross total resection. R = craniotomy surgical details unknown. ** = This patient had a diagnosis of gliosarcoma. The mean age of patients 1–11 is 48.4 years. The mean age of patients 12–23 is 54.7 years.Characteristics of patients with GBM at first recurrence.