Clinical performance of methylation biomarker and HPV to detect CIN3+ /CIS and complex hyperplasia of endometrium in AGC.

Abbreviations: AGC, atypical glandular cell; CIN3, cervical intraepithelial neoplasia type 3. The case number of AGC is 55, and the case number of CIN3+ is 7.1Methylation-Index (M-Index): the value cut off for precancer/cancer patient (cervical intraepithelial neoplasia grade 3 and worse, CIN3+) or not (CIN2-, including normal specimens, and CIN1 and CIN2 specimens).2The area under the ROC curve (AUC) with 95% confidence interval (CI) of each gene was calculated for the diagnosis of CIN3+ compare with control (CIN2-).Clinical performance of methylation biomarker and HPV to detect CIN3+ /CIS and complex hyperplasia of endometrium in AGC.